- Title
- Inflammatory aetiology of human myometrial activation tested using directed graphs
- Creator
- Bisits, Andrew M.; Smith, Roger; Mesiano, Sam; Yeo, George; Kwek, Kenneth; Macintyre, David; Chan, E.-Cheng
- Relation
- PLoS Computational Biology Vol. 1, Issue 2, p. 0132-0136
- Publisher Link
- http://dx.doi.org/10.1371/journal.pcbi.0010019
- Publisher
- Public Library of Science
- Resource Type
- journal article
- Date
- 2005
- Description
- This paper describes how novel computational approaches have been used to test hypotheses for important physiological events when the traditional approaches of animal studies and experiment are not possible. The processes that regulate the onset of human labour are presently unknown, principally because there are no good animal models for human pregnancy and because it is unethical to conduct experiments on pregnant women undergoing labour. However, several hypotheses have been advanced to explain the trigger for labour, including: a functional withdrawal of the hormone progesterone, increased inflammation in the uterus, and increased signalling through the hormone oxytocin. To test these hypotheses the researchers used data on the messenger RNA concentrations of critical variables in samples of uterine muscle taken from 12 women undergoing caesarean section prior to labour and 12 women during labour. Directed graphs for each of the proposed hypotheses were then generated, where the graphs represent the direction of causal influence between different variables. Statistical testing determined how well the graphs of each hypothesis matched the experimental data. The results strongly support an inflammatory origin for the onset of human labour. This approach could be applied to other problems in human biology where the traditional approaches of experiments and animal models are not possible.
- Subject
- human myometrial activation; human labour
- Identifier
- http://hdl.handle.net/1959.13/27277
- Identifier
- uon:1515
- Identifier
- ISSN:1553-734X
- Rights
- © 2005 Bisits et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Language
- eng
- Full Text
- Reviewed
- Hits: 5725
- Visitors: 6535
- Downloads: 483
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | Attachment02 | Publisher version (open access) | 148 KB | Adobe Acrobat PDF | View Details Download |